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Tofacitinib citrate 540737-29-9 Rheumatoid arthritis Anticancer

Whakaahuatanga Poto:

kupu taurite:CP-690550 (Tofacitinib citrate);(3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine 2 -hydroxy-1,2,3-propanetricarboxylate

Nama CAS:540737-29-9

Kounga:i roto i te whare

Tātai rāpoi:C16H20N6O.C6H8O7

Taumaha tātai:504.49


Taipitopito Hua

Tohu Hua

Utu:T/T, L/C
Takenga Hua:Haina
Tauranga Tukunga:Beijing/Shanghai/Hangzhou
Te kaha whakaputa:100kg/marama
Raupapa(MOQ):25kg
Wā Arataki:3 Nga Ra Mahi
Tikanga rokiroki:Whakaorangia ki te waahi makariri, maroke, te pāmahana rūma.
rauemi mōkihi:pahū
Rahi mōkihi:25kg/pahū
Nga korero haumaru:Ehara i nga taonga kino

Tofacitinib citrate

Kupu Whakataki

Ko te Tofacitinib, he rongoa e whakamahia ana ki te rongoa i te mate rūmātiki, te mate pukupuku psoriatic, me te ulcerative colitis.

Ka whakamahia te Tofacitinib citrate ki te rongoa i nga pakeke e mate ana i te mate rumati rūmātiki tino kaha ki te kore e tika te whakautu ki te methotrexate.

Ko te Tofacitinib citrate e tohuhia ana mo te maimoatanga o te ngawari ki te kaha o te mate rūmātiki (RA) i roto i nga pakeke kaore i te pai te whakautu ki a ratau, kaore ranei e aro ki tetahi, neke atu ranei nga raau taero antirheumatic.

Whakatakotoranga (i roto i te whare)

Tūemi

Whakatakotoranga

Te ahua

Te paura tioata ma, he ma ranei

Tautuhinga

IR, HPLC

Wai

≤1.5%

Nga Taonga Paanga

TOFA 06 ≤0.15%

Tofacitinib trans isomer ≤0.15%

Tofacitinib dehydrogenated ≤0.15%

Ia poke unknown ≤0.10%

Tapeke Whakakore: ≤1.0%

Wairewa toenga

Ewaro ≤5000ppm

Benzene ≤2ppm

Toluene ≤890ppm

Chlroroethane ≤1000ppm

N,N-Dimethylformamide ≤800ppm

Palladium ≤10ppm

Dichloromethane ≤600ppm

Te pungarehu ngongo

≤0.1%

Kounga Taumaha

≤10ppm

HPLC Chria

3S, 4S tofacitinib ≤0.15%

Whakamātautau (i runga i te tikanga kore wai) 98.0-102.0%


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