Tacrolimus monohydrate 109581-93-3 Antibiotic
Utu:T/T, L/C
Takenga Hua:Haina
Tauranga Tukunga:Beijing/Shanghai/Hangzhou
Te kaha whakaputa:1kg/marama
Raupapa(MOQ):1g
Wā Arataki:3 Nga Ra Mahi
Tikanga rokiroki:Whakaorangia ki te waahi makariri, maroke, te pāmahana rūma.
rauemi mōkihi:pounamu, pounamu
Rahi mōkihi:1g/pounamu, 5/putea, 10g/pounamu, 50g/pounamu, 500g/pounamu
Nga korero haumaru:UN 2811 6.1/PG 3
Kupu Whakataki
Ko te Tacrolimus, he rongoa immunosuppressive.Whai muri i te whakawhitinga okana allogeneic, he iti te tupono o te whakakore okana.Hei whakaiti i te tupono o te whakakorenga okana, ka tukuna he tacrolimus.Ka taea hoki te hoko i te rongoa hei rongoa mo te rongoa mo nga mate-whakawaenga-T penei i te eczema me te psoriasis.Ka taea te whakamahi hei rongoa i te mate kanohi maroke i roto i nga ngeru me nga kuri.
Ka aukati a Tacrolimus i te calcineurin, e uru ana ki te hanga i te interleukin-2, he ngota ngota e whakatairanga ana i te whakawhanaketanga me te tipu o nga pūtau T, hei waahanga o te ako a te tinana (he urutau ranei) te urupare aukati.
Whakatakotoranga (USP43)
| Tūemi | Whakatakotoranga |
| Te ahua | Te paura tioata ma, tata ma ranei |
| Tautuhinga | IR, HPLC |
| Wairewa | He tino wairewa ki te methanol, he whakarewa noa i roto i te N,N dimethylformamide me te waipiro, tata ki te wairewa ki te wai. |
| Te toenga i runga i te mura | ≤0.10 % |
| He poke pararopi (tikanga-2) | Ascomycin 19-epimer ≤0.10 % |
| Ascomycin ≤0.50 % | |
| Desmethyl tacrolimus ≤0.10 % | |
| Tacrolimus 8-epimer ≤0.15 % | |
| Tacrolimus 8-propyl analog ≤0.15 % | |
| Te poke kore mohiotia -I ≤0.10 % | |
| Te poke -II ≤0.10 % | |
| Te poke kore -III ≤0.10 % | |
| Tapeke poke ≤1.00 % | |
| Te hurihanga whatu (i runga i te tikanga) (10mg/ml i roto i te N,Ndimethylformamide) | -110.0° ~ -115.0° |
| Ihirangi wai (na KF) | ≤4.0% |
| Te toenga whakarewa (na GC) | Acetone ≤1000ppm (I-whare) |
| Di-isopropyl ether ≤100ppm (I-whare) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Te whakamatautau moroiti (i roto i te whare) | Katoa moroiti aerobic tatau ≤100cfu/gm |
| Katoa te rewena me te tatau pokepokea ≤10cfu/gm | |
| Ko nga rauropi kua tohua (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) me ngaro | |
| Te whakamatautau (ma te HPLC) (i runga i te waikore me te whakarewa kore utu) | 98%~102% |
