Orlistat 96829-58-2 Antiobesity Diet tāpiritanga
Utu:T/T, L/C
Takenga Hua:Haina
Tauranga Tukunga:Beijing/Shanghai/Hangzhou
Te kaha whakaputa:800kg/marama
Raupapa(MOQ):25kg
Wā Arataki:3 Nga Ra Mahi
Tikanga rokiroki:Whakaorangia ki te waahi makariri, maroke, te pāmahana rūma.
rauemi mōkihi:pahū
Rahi mōkihi:25kg/pahū
Nga korero haumaru:Ehara i nga taonga kino
Kupu Whakataki
Ko Orlistat he mahi roa me te kaha o te aukati lipase gastrointestinal motuhake.He ma, tata ma ranei te paura i te pāmahana rūma, he kore e rewa ki te wai, he rewa ki te chloroform, he ngawari ki te waiwaro.Ka whakakorehia e ia te enzyme ma te hanga i nga here kovalent ki nga waahi serine kaha o te lipase pekiti me te lipase pancreatic i roto i te puku me te whekau iti.
Ko Orlistat tetahi momo raau taero whakaheke taumaha lipase.He pärönaki hydrated o te lipstatin, ka taea te whakaiti i te whakaurunga o te ngako kai me te whakaiti i te taumaha.Ko tenei hua he kaha te aukati i te lipase pekitīlia me te lipase pancreatic, kaore he painga ki etahi atu enzymes keri (amylase, trypsin, chymotrypsin) me te phospholipase, kaore e pa ki te whakauru o te warowaihā, te pūmua me te phospholipids.Ka whakakorehia e ia te enzyme na roto i te here covalent me nga toenga serine i nga waahi kaha o te lipase pekitīlia me te lipase pancreatic i roto i te kopa gastrointestinal, ka aukati i te hydrolysis o te triacylglycerol, ka whakaheke i te whakauru o te monoglyceride me te waikawa ngako kore utu, na reira ka whakahaere i te taumaha tinana.Ko te raau taero kaore i te uruhia e te gastrointestinal tract, ka taea te whakakore i te lipase.
Ko tenei hua ano te mahi ki te whakahaere i nga lipids toto.Ka taea e ia te whakaheke i te triglyceride me te iti-kiato lipoprotein cholesterol i roto i te serum o te hunga mate momo me te whakanui ake i te ōwehenga o te lipoprotein teitei ki te lipoprotein iti.
Ki te whakakotahihia te orlistat me te kai iti kawa, he pai mo te maimoatanga mo te wa roa mo te hunga momo me te taumaha, tae atu ki te hunga kua whakawhanake i nga mea morearea e pa ana ki te momi.Kei a ia nga mahi whakahaere taumaha mo te wa roa penei i te whakaheke taumaha, te tiaki taumaha me te aukati i te rebound.E whakaatu ana te haumanu he tino whai hua te mahi whakahaere taumaha mo te whakamahi mo te wa roa i te wa e kai ana te kamupene ki te kai, i muri ranei i te haora o te kai.
Ka taea e Orlistat te whakaheke i te reeti o te mate morearea e pa ana ki te momi me etahi atu mate e pa ana ki te momi, tae atu ki te hypercholesterolemia, te mate huka momo II, te ngoikoretanga o te hukahuka, te hyperinsulinemia, te whakaheke toto, me te whakaheke i te ngako i roto i nga whekau.
Whakatakotoranga (USP42)
| Tūemi | Whakatakotoranga |
| Tautuhinga | HPLC, IR |
| Te hurihanga whatu motuhake | -48.0°~-51.0° |
| Te ihirangi wai | ≤0.2% |
| Matū whai pānga I | Pūhui pātahi Orlistat A ≤0.2% |
| Matū whai pānga II | Pūhui Pānga Orlistat B ≤0.05% |
| Matū whai pānga III
| Formylleucine ≤0.2% |
| Pūhui whai Orlistat C ≤0.05% | |
| Orlistat mowhiti tuwhera epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Te poke takitahi ≤0.1% | |
| Matū whai pānga IV | Pūhui pātahi Orlistat D ≤0.2% |
| Orlistat tuwhera mowhiti amide ≤0.1% | |
| Matū whai pānga V | Pūhui pātahi Orlistat E ≤0.2% |
| Katoa nga poke (I ki V) | ≤1.0% |
| Te toenga whakarewa | Mewaro ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Te toenga i runga i te mura | ≤0.1% |
| Ko nga konganuku taumaha hei Pb | ≤20ppm |
| He whakamatautau na HPLC | 98.0%~101.5% (i runga anhydrous, whakarewa-kore pūtake) |
